Androgen receptor signalling in peritubular myoid cells is essential for normal differentiation and function of adult Leydig cells
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چکیده
منابع مشابه
Androgen receptor signalling in peritubular myoid cells is essential for normal differentiation and function of adult Leydig cells.
Testosterone synthesis depends on normal Leydig cell (LC) development, but the mechanisms controlling this development remain unclear. We recently demonstrated that androgen receptor (AR) ablation from a proportion of testicular peritubular myoid cells (PTM-ARKO) did not affect LC number, but resulted in compensated LC failure. The current study extends these investigations, demonstrating that ...
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Androgens are essential for normal spermatogenesis and male fertility, but how androgens exert this effect remains uncertain. Androgen receptors (ARs) are expressed in several testicular cell types, but continuing uncertainty exists over which cell type mediates androgen control of spermatogenesis. Androgen signaling via Sertoli cells (SCs) is essential for complete spermatogenesis, but the rol...
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Sertoli cells (SCs) regulate testicular fate in the differentiating gonad and are the main regulators of spermatogenesis in the adult testis; however, their role during the intervening period of testis development, in particular during adult Leydig cell (ALC) differentiation and function, remains largely unknown. To examine SC function during fetal and prepubertal development we generated two t...
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ژورنال
عنوان ژورنال: International Journal of Andrology
سال: 2011
ISSN: 0105-6263
DOI: 10.1111/j.1365-2605.2011.01150.x